Since early 1970s there have been performed experiments aimed to investigate the fragmentation of the lightest nuclei (d, ³H, ³He, and ⁴He) on protons at intermediate energies (~0.2-2 GeV per nucleon). These experiments were set up in ITEP and LHE JINR and realized in an exclusive approach with the help of liquid-hydrogen bubble chambers. This investigation is of great interest from two points of view: 1) possibility of detailed theoretical analysis of the data obtained in 4p-geometry on the basis of good understanding of these nuclei wave function structure; 2) search for exotic interaction mechanisms. The overview presents the latest most interesting results of the ITEP experiment on the study of ⁴Hep interactions at ⁴He nuclei momenta of 2.7 and 5 GeV/c on cross sections, elastic scattering, pair correlations of secondary nucleons, cumulative production of nucleons and the lightest nuclei (d, ³H, and ³He), main features of exclusive reactions, search for possible multiquark bag production (dibaryons and tribaryons). The essential results of independent JINR experiment at 8.6 and 13.6 GeV/c are also under discussion.

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